High Intensity Exercise- A Factor For Renal Medullary Carcinoma

  • April 04, 2021



D.D. Shapiro, M. Soeung, +22 authors P. Msaouel Published an article in medRxiv 2021 that renal medullary carcinoma (RMC) predominantly occurs in individuals with sickle cell trait (SCT). We found that patients with RMC more frequently participated in high-intensity exercise than matched controls, and renal medullary hypoxia significantly increased predominantly in the right kidney of mice with SCT following high- but not moderate-intensity exercise, consistent with the distinct predilection of RMC toward the right kidney. These results establish high-intensity exercise as a risk factor for RMC in individuals with SCT. For more information, click High intensity exercise