Ms Ferguson, who leaves behind her daughter Nova-Noelle, three, first spoke of her renal medullary carcinoma in 2016.
Renal medullary carcinoma is a rare form of kidney cancer which is particularly aggressive and fast-spreading. It is not clear how many people get the disease.
Ms Ferguson revealed how she kept going to her doctor complaining of kidney infections but they repeatedly sent her home.
After around seven months of continual pain, she was referred to Manchester Royal Infirmary for a biopsy and scans.
Ms Ferguson was then diagnosed with the cancer. Surgeons removed her kidney and said they hoped that would ‘be the end of it’.
Speaking to the Manchester Evening News in 2016, she said: ‘It’s one of the rarest forms of kidney cancer and nothing works for it.
‘The longest survivor has lived for eight years. It’s incurable at the moment. When I first found out it was horrible. My life flashed before me.’
Ms Ferguson said she would do ‘anything I can to beat this’ and even revealed how she turned vegan in hope that it may help her.
The family had begun trying to raise £60,000 for treatment in Germany, although it is unclear what the therapy was.
In an emotional Facebook post when her sister died, Renacia said: ‘As some of you may know my sister Rhianna Ferguson passed away last night in her sleep.
‘Breaks my heart to even write those words. She was always my right arm and my biggest inspiration.
‘She gave the fight of her life and I’m so proud to call her my sister. She fought so hard but Rhianna, you said you were tired of this and wanted it to be over.
I know we never thought it would be over this way, but I just want to hug you and tell you everything is going to be OK, you’re not in pain no more you don’t have to fight no more.
‘Nova-Noelle will ALWAYS know what and amazing mummy she has and how much you loved her.
‘She’s just like you Rhianna, a Rhianna part two, so I know she will be OK and just as strong as her mummy and make you proud.’
Her post continued: ‘All I can say is just rest now Rhianna cos God knows you deserve it just rest and be at peace, because you haven’t had that for years.
‘I love you so much and I’m so happy to have had a sister who taught me so much. I will make you proud, we all will.
‘I will see you soon Rhianna. Love you with every single bone in my body.’
Friends have also been paying tribute to Ms Ferguson on Facebook.
By STEPHEN MATTHEWS HEALTH EDITOR FOR MAILONLINE and SAM BLANCHARD HEALTH REPORTER FOR MAILONLINE
PUBLISHED: 07:30 EDT, 4 February 2019 | UPDATED: 07:38 EDT, 4 February 2019
The Chris “CJ” Johnson Foundation Inc., extends their condolences to the family of Rhianna. We will be praying for her daughter, age 3 as well.